Magnetic Fields and Cancer Treatment

I have never been a proponent of saying that PEMFs alone should be used to treat cancer. The most humbling thing I can say about the treatment of cancer is that there are no perfect solutions. I would also say there is no such thing as a cure.

No such thing as a cure

Cancer is a chronic illness. Even though you have been declared “cured” by a doctor, usually defined as surviving beyond 5 years after diagnosis, there is almost lifelong vigilance and surveillance to be sure the cancer has not come back. Yes, you can effectively be in a state of long-term remission after an original diagnosis. Unfortunately, very many people do not live beyond 5 years or for that matter beyond 10 or even 15 years after their diagnosis. So, medicine today continues to search for answers in the war on cancer, to find a cure.

To me the real issue is not necessarily to find a cure, even though that is certainly a desirable goal, but rather to find ways of making our current therapies more effective to produce longer-lasting results with a better quality of life. So often, current medical therapies are brutal, making people very ill, with often poor results nonetheless. Yes, certainly, in many cases the therapies do produce long-lasting benefits, but this is often uncertain and unpredictable.

Enhancing existing therapies with PEMFs

How can we make the results of medical therapies more certain and more predictable? PEMF therapies may be one approach to enhancing the value of existing therapies. The research available to support the use of PEMFs in the setting of cancer is still far from being of great certainty. Of course, the same can be said of most existing medical therapies. So, the question is what is the harm? The harm comes largely from uncertainty. Conventional medical therapies still have a huge level of uncertainty as well, but they are sanctioned by society and the medical community. That makes them acceptable, even though they are very often ineffective. Because PEMFs are not as acceptable, and because the science is not compelling, to convince most doctors or most guideline and professional bodies, they are considered to be “unacceptable”. That being said, most doctors however are completely ignorant about what PEMFs do biologically and physically. And, unfortunately, they are not even willing to explore these approaches. Likewise, most doctors are not even willing to approach and consider nutritional aspects of managing cancer. As a result, the consumer and the person suffering from cancer, is largely left on his/her own.

Perhaps we can shed a little bit of light on this issue with the potential use of PEMFs with 2 recent studies that have been reported. One is in humans and one is in animals. Even conventional medical oncology sometimes resorts to relying on animal studies, in the absence of any available human studies. Since you can’t always conclude that the results from animal studies can be applied to humans, drawing conclusions from animal studies needs to be done with some caution. However, I’m of the belief that individuals are responsible for their own health and will ultimately make their own best personal decisions.

Human Study

In the human study, done in China, magnetic fields were studied in the treatment of patients with advanced cancers of various kinds. Unfortunately, the entire article is a written in Chinese, so it is not available in complete form to us. In this study, 137 patients with advanced malignant tumors were exposed to what amounts to a sinusoidal magnetic field of approximately 7 Hz, at 4000 Gauss, for 2 hours a day for between 30 to 50 days. The clinical benefit was 60%. 28 patients had a complete response and 54 had a partial response. The median overall survival was 12 months. The 1-year, 2-year and 3-year survival rates were 47.0%, 11.8%, 3.4%, respectively. Complications were minimal. There were no treatment related deaths. Unfortunately, the survival rates in individuals with advanced cancers normally tend to be very poor. If life can be extended comfortably, this could be a very important benefit. So, the type of PEMF used in this study seems to have improved the quality of life of these individuals and probably in many cases prolonged survival. It is well known in the medical community that people with advanced cancers do very poorly. Medical therapies in these people are largely experimental and likewise have poor results.

While we don’t have commercially available PEMFs exactly the same as those used in this study, we do have available PEMF systems that are of a comparable intensity with a similar frequency. However, these devices are often very expensive and need to be used for extended periods of time, that is, 2 hours per day, on a daily basis, for extended periods of time, for months, if not the rest of the person’s life. It is not known if treatment extended beyond the 30 to 50 days used in this study would have produced even better results. Nonetheless, these results are very impressive, despite the limited length of time the treatment was used. Since often these treatments are applied in doctors’ offices, the treatment durations are probably too short. Even if available PEMFs are not exactly comparable to those used in this study, available devices have the potential to produce similar results. In the end, there is no harm, from what this study shows, in trying. In my clinical experience patients using PEMFs on an ongoing basis, in the home setting, long-term, with or without conventional therapies do better and are much more comfortable.

Ref: Han JQ, Liu Q, Sun CT, Yao J, Zhao B, Wang H. Efficacy and safety of low-frequency rotary magnetic fields in the treatment of patients with advanced malignant tumors. [Article in Chinese] Zhonghua Zhong Liu Za Zhi. 2013 Jun;35(6):468-71.

Animal Study

Another study looked at the use of pulsed electric fields in breast cancer in mice. Electric fields have both an electric and magnetic aspect to them, Very short pulse length pulsed electric fields, which didn’t create heating to destroy tissue were used. The frequency was 4 hertz. Two weeks after treatment, the growth of treated tumors was inhibited by 79%. MRI was used to assess the physical changes in the tumors. Various growth factors, including the development of new blood vessels were strongly suppressed. As a control, normal skin was treated the same way as the tumors and showed no permanent changes. So, tumors react differently to PEMFs, in a positive fashion, than normal tissue. The results suggest short pulse electromagnetic fields may be able to inhibit human breast cancer development and suppress tumor blood vessel growth, and may therefore serve as a novel therapy for breast cancer.

Ref: Wu S, Wang Y, Guo J, Chen Q, Zhang J, Fang J. Nanosecond pulsed electric fields as a novel drug free therapy for breast cancer: An in vivo study. Cancer Lett. 2013 Oct 4. S0304-3835(13)00701-5.

Conclusion

These 2 studies show us that PEMFs have significant potential in helping patients with cancer, advanced or otherwise. Obviously, a great deal more research needs to be done to discover the best signals and approaches. It remains to the individual to determine whether using PEMFs along with their conventional approaches is something they might want to consider. As a physician, I can’t tell you whether this is your best option. I feel comfortable, however, knowing what I know about PEMFs and their benefits, that PEMFs can be a very important addition to whatever approach to cancer treatment an individual may choose. At this point, suffice it to say, nobody has a perfect solution.

Common Emotional Responses to Cancer Treatment

Although much is written of the physical side effects associated with the treatment of cancer, many people are aware of the full scale of emotional impact cancer treatments can have on a patient. Such treatments can result in a broad spectrum of emotions, from fear to elation and everything in between.

The primary concern of all cancer treatments is to rid the body of a cancerous growth. It’s important though to pay close attention to the emotional effects of the illness too. Failure to do so can lead to depression and a number of other mental health conditions.

Below is a look at some of the more common emotional responses associated with the treatment of cancer:

FEAR
Many feelings experienced during the treatment of cancer can be likened to those associated with the initial diagnosis. The most obvious of these is fear. It’s completely natural to be scared of what is an extremely potent disease, and this doesn’t necessarily end once you’ve gone under the knife. Even if surgery or chemical therapies are successful, many survivors fear that the cancer will return. This fear often manifests itself in a variety of ways, including fearing for the future of loved ones and worrying that friends and colleagues will treat you differently.

UNCERTAINTY/CONFUSION
There is a lot to take in when it comes to cancer treatments. Understanding the disease and how it will be treated is enough, but you also have to cope with the financial, work, family, and day-to-day aspects of your life. It’s not surprising then that cancer patients get confused. Juggling this much information is tough so it’s important to try and share the workload wherever you can. It’s worth pointing out that it’s quite common for patients to be unsure whether to proceed with treatment or tell loved ones. Such uncertainties shouldn’t alarm you, but it’s vital that you pay close attention to them.

DISILLUSIONMENT
Disillusionment is particularly common with those that find cancer treatments are initially unsuccessful. The treatment of cancer can be a very long journey, so it’s only natural to have a few negative thoughts as you go along. This may present itself by feeling disappointed by your family or let down by your doctors. Even those with a strong faith have found themselves questioning their god after being diagnosed with cancer.

APATHY
For some, the treatment of cancer lends itself to feelings of apathy. Some people feel there is absolutely nothing they can do to impact the success of treatment so they prefer not to think about it. Other feel there is no chance of survival (which is ordinarily not the case in these days of advanced medical treatments) so they adopt the ostrich effect and bury their heads in the sand. Like disillusionment, this is more common in those that face at least one unsuccessful stage of treatment. It may manifest itself as a disinterest in leaving the house, eating, communicating, sex, or a number of other manners. Apathy can be very dangerous to the patient. Prolonged periods of apathy will have a negative impact on a person’s mental health which in turn can hinder successful treatment.

ISOLATION
Some people find that they feel isolated during cancer treatments. Long treatment periods may take them away from work and seeing their friends, while family ties can be weakened due to the stress and strain. This in turn may generate the feeling of isolation.

ELATION
Of course, the treatment of cancer doesn’t only bring sorrow and misery with it. Plenty of patients are overjoyed after successful cancer treatments and thankful for another chance. Likewise, many are also relieved and optimistic for the future.

The above list features just a sample of the emotions that you may feel during and after cancer treatments. It’s unlikely that you will experience all of these, although it is possible, especially if your treatment of cancer is prolonged across a number of months or years. Similarly, there is no guarantee that you’ll experience any of those listed above.

It’s important to remember that there are many other feelings that may impact you during this time. It’s best then to pay close attention to how you feel and always follow-up anything concerning you with your doctor.

Cancer Treatment Options Abound for Cancer Patients

Whenever the word “cancer” is mentioned, many people jump to the conclusion that chemotherapy is the only treatment option available. This could not be further from the truth.

Chemotherapy is one of the many treatments available for cancer and is often used in a combination of treatments, or not used at all. While the main treatment of cancer may have been chemotherapy in the past, new technology and further research are continuing to allow for evolving cancer care options in Nevada and around the world.

At Sierra Nevada Cancer Center, a few methods are used to treat cancer. Biological therapies, cancer vaccines, and immunotherapy are all used as effective treatments of cancer — in addition to chemotherapy.

This post will provide a broad description of a few of these treatment options. But remember: Your oncologist will determine your best course of treatment based on your specific cancer and history.

Biological Therapies

Biological therapies are therapies that use your body’s natural defense system to fight cancer itself, the effects of cancer or the effects of other treatments of cancer. The National Cancer Institute further explains biological therapies: “Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease.”

Dr. Jorge Perez, MD, PhD, MRCP, MRCPath, and his staff at Sierra Nevada Cancer Center keep themselves well-versed on the latest and most effective treatments of cancer available, like biological therapies, to bring better cancer care in Nevada.

Cancer Vaccines

Cancer vaccines can be used in the treatment of cancer to stimulate or repair parts of your body’s immune system to promote the defense against cancer or your body’s ability to fight cancer itself. There are two kinds of cancer vaccines: preventative vaccines and treatment vaccines.

• Preventative vaccines are designed to protect individuals from getting cancer by vaccinating them against diseases and viruses that could lead to cancer, like human papillomavirus (HPV).

• Treatment vaccines treat existing cancer by strengthening the body’s ability to fight cancer cells.

Immunotherapy

Immunotherapy is a kind of biological therapy that aims to teach your immune system to specifically target cancer cells or to give a general boost to your immune system. Immunotherapy can be effective to treat certain kinds of cancer, like lung cancer, on its own, but is typically used in conjunction with other kinds of cancer treatment.

“In the last few decades immunotherapy has become an important part of treating some types of cancer,” reports the American Cancer Society.“Newer types of immune treatments are now being studied, and they’ll impact how we will treat cancer in the future.”

“Cancer”- types and treatment

Cancer is considered as a genetic disease. This genetic disease, cancer can be hereditary or may be due to certain environmental exposures. The environmental exposures that cause damage in DNA chemicals are present in tobacco smoke, and radiation (ultraviolet rays from the sun). These environmental exposures cause the body cells to divide in an unstable manner resulting cancer. The genes responsible cancer are of three types

• Proto-oncogenes

• Tumor suppressor genes

• DNA repair genes

The genetic changes that cause cancer are known as “Drivers” of cancer

Types of cancers

There are about hundred types of cancer. But the types of cancer are usually named for the organs or tissues where the cancers form. Let us discuss some categories of cancer

Carcinoma

Cancer happens in the epithelial cells are called as carcinoma. Some types of Carcinoma.

• Adenocarcinoma,

• Basal cell carcinoma ,

• Squamous cell carcinoma,

• Transitional cell carcinoma

Sarcoma

Cancer occurring in bones and soft tissues are called as Sarcoma. Types of Sarcoma

• Osteosarcoma,

• Leiomyosarcoma,

• Kaposi sarcoma,

• Malignant fibrous histiocytoma,

• Liposarcoma

• Dermatofibrosarcoma protuberans

Leukemia

Cancer seen in bone marrow is called as Leukemia. Leukemia is not solid tumors. An example of one type of leukemia is acute lymphoblastic leukemia.

Lymphoma

Cancer occurring in the lymphocytes (T cells or B cells) are called Lymphoma. There are types of Lymphoma and they are

• Hodgkin lymphoma

• Non-Hodgkin lymphoma

Multiple Myeloma

Cancer occurring in the plasma cells (immune cell) is called as Multiple Myeloma. This Multiple Myeloma also called as plasma cell myeloma and Kahler disease.

Melanoma

Cancer occurring in the melanocytes, cells that make melanin pigment

Brain and Spinal Cord Tumors

These tumors are named based on the type of cell in which they formed and where the tumor first formed in the central nervous system. Some examples of brain or spinal cord tumors are

• astrocytic tumor

• Brain tumors

Other Types of Tumors

Germ Cell Tumors

Germ cell tumors originate from sperm or eggs cells

Neuroendocrine Tumors

This type of neuroendocrine tumors originates from hormone-releasing cells which respond to signal from the nervous system

Carcinoid Tumors

Carcinoid tumors are commonly seen in the gastrointestinal system. This type of Carcinoid tumors is slow-growing tumors.

Symptoms of cancer

The symptoms of cancer in men are given below.

• Bowel changes

• Rectal bleeding

• Urinary changes

• Blood in urine

• Persistent back pain

• Unusual coughing

• Testicular lumps

• Excessive fatigue

• Unexplained weight loss

• Lumps in the breast

The symptoms for cancer in women are given below

• Abnormal vaginal bleeding

• Unexplained weight loss

• Vaginal discharge colored with blood

• Constant fatigue

• Swollen leg

• Loss of appetite or feeling full all the time

• Pain in the pelvis or abdominal area

• A bloated belly

• Constantly needing bathroom breaks

• Persistent indigestion or nausea

Treatments for cancer

Cancer treatments include:

• Surgery

• Radiation Therapy

• Chemotherapy

• Immunotherapy

• Targeted Therapy

• Hormone Therapy

• Stem Cell Transplant.

• Precision Medicine.

Patient expertise: Cervical cancer treatment in early stage

Greater than 11,000 American ladies advance cervical melanoma each and every yr. Nevertheless, cervical melanoma is a treatable and there is an excellent hazard of cure if the cancer is determined and dealt with in the early stages.

The Cervix

The uterus opens into the vagina through the cervix. Squamous cells make up the outer layer of the cervix. Squamous mobile carcinoma of the cervix is the title for melanoma that influences these cells.

The cervix also includes glandular cells, which line the hole of the cervix and the canal that leads into the uterus. These cells may additionally come to be cancerous; after they do, they are referred to as adenocarcinomas of the cervix. Despite the fact that they arise from unique forms of cells, squamous telephone carcinoma and adenocarcinoma of the cervix are handled in a similar fashion within the early stages.

Cervical Cancer Risk Factors

The most usual threat element for cervical melanoma medication is contamination with a plague called human papilloma virus (HPV). HPV is spread by way of direct dermis-to-skin contact, together with sexual intercourse, oral sex, anal intercourse or any other contact involving the genital area. HPV contamination may additionally rationale a noncancerous condition known as condyloma.

Most HPV infections are transitorily since the body’s immune method readily clears the infection. When distinct forms of the HPV virus persist in the physique, there is a larger likelihood that the viral illness will motive cervical telephone abnormalities similar to dysplasia or melanoma; chronic infections are believed to arise in 10 to 20 percent of females. Proof of HPV contamination can also be detected in just about all cervical cancers.

Cervical Cancer Symptoms

Mainly, cervical cancer treatment improves slowly over an interval of several years. In some ladies, the cancer does not motive any signs, at the same time in others it explanations abnormal vaginal bleeding or discharge. This can include bleeding between menstrual intervals, bleeding after intercourse, or bleeding after menopause. This bleeding could also be not more than a spot of blood.

Abnormal bleeding can also be caused by a number of other conditions, not related to cancer treatment. If you have abnormal vaginal bleeding, make an appointment to see your doctor or nurse.

Cervical Cancer Diagnosis

Cervical cancer cure is identified with a cervical biopsy. A biopsy includes eliminating a small piece of tissue. The biopsy is performed throughout an office talk over with utilizing a procedure referred to as colposcopy. The colposcope magnifies the cervix. This permits the clinician to better see the place, extent and measure of very small abnormalities that will not be seen with the naked eye on my own.

The tissue obtained for the period of the biopsy is analyzed with a microscope to look if cervical cancer cells are gift. In some circumstances, a larger biopsy called cervical conization is needed. This can also be carried out within the working room with a scalpel or within the place of job making use of loop electro excision method.

If a biopsy shows cervical cancer, you must see a health care professional who makes a specialty of cancers of the female reproductive method.

Looking For Inexpensive Treatment For Cancer? Travel To India

In 2012, the number of new cancer cases diagnosed across the world was 14.1 million. The number of cancer deaths worldwide was 8.2 million in 2012 . The number of new cancer cases expected to be diagnosed in 2030 is 21.7 million, and 13 million cancer deaths are predicted by 2030. But, these predictions only reflect population growth as well as aging, thus these figures will likely be much larger because of the adoption of lifestyles that are known to increase cancer risk, like smoking, physical inactivity, and poor diet.

But, if there are deadly diseases, then there are great hospitals as well. Now that you’ve found that you or any of your beloved ones has become the victim of Cancer, then it’s time to look for the Best Hospital for Cancer Treatment in India, such as Tata Memorial Hospital, Mumbai, Fortis Hospital Jaipur, Apollo cancer hospital Chennai and many others.

The most common types of cancer found are Bladder Cancer, Colon & Rectal Cancer, Endometrial Cancer, Breast Cancer Kidney Cancer and Leukemia. However, nearly all types of cancer can be prevented with proper treatment.

What Is Cancer?

Cancer is a group of diseases defined by uncontrolled growth and spread of abnormal cells. It can result in death if the spread is not con-trolled. Cancer is caused by external factors such as tobacco, radiation, chemicals and infectious organisms, and also by internal factors like inherited mutations, mutations and hormones, immune conditions that occur from metabolism.

Why choose India?

A lot of patients from other countries are travelling to India for cancer treatment as the whole procedure is conducted at lesser price than the hospitals abroad. In addition to this, the metropolitan cities of India like Delhi, Mumbai, Bangalore, Hyderabad, Chennai and Kolkata, have some of the best speciality hospitals providing state of the art facilities. Also, the rate of success of the cancer surgeries is about 80 to 90 percent in India.

Cancer treatment in countries like the USA and UK is very expensive as well as prohibitive. Also, there is a good chance that people are suffering from cancer prefer to die instead of risk financial ruin for their families. But, India provides a good alternative for expensive treatment at very affordable costs.

Apart from this, medical tourism companies in the country help patients not just in getting the right hospital, but in applying for visas and other immigration procedures as well. Cancer hospitals provide help to family members who might want to travel with their patient as well.

Laser treatment for cancer patients is more effective procedure than surgery

Liver carcinoma will be progressively taken shot in the arm of by way of doing thing of laser light completely medical procedures ubiquitous specific centers. Breast carcinoma will be taken benefit of by approach of copious centers globally by ablation as an up to the individual to bring to open surgery. Treatment associated by the whole of lasers in cancer treatment in Mumbai has been slacken but steady. Physicians are adapting to this around new what under the hood across the world. Right forthwith lasers works fully well omnipresent 70% associated by the whole of Non laparoscopic General Surgical assistance however the power is very constrained currently. Laser Surgical benefit differs by ministry scalpel medical procedures. It offers the riches of getting all of a sudden, late in basic principle to truly no pain acknowledge op.

Cyto-reduction cut back be a sincere strategy that wills sink in how noteworthy advanced corruption makes Radiotherapy in presentation to chemotherapy greater appropriate overall work the bugs out of associated by the whole of advanced cancers.

The consequently approaches that masses gave a pink slip reside as a fixed attitude of gift-

Radiofrequency ablation method
Surgical treatment

Cryosurgery process
Microwave technology
Laser technology

Oral cancers or perchance mouth cancers can be a subtype associated by generally told of throat cancers, is ready entire hanging by a thread cells wealth found in the mouth area. It commit well get up to be a practice lesion proceeding in from whole of the oral ties of blood, by way of doing thing of metastasis from a easily away home ground associated by the whole of source, or reasonably by way of doing thing from a nearby anatomic definite plan, a well known as the nasal tooth cavity.

You should execute that close but no cigar 75% associated with oral cancel are linked by all of flexible conducts equally cigarette smoking employ in presentation to increased consume use. Different variables include can’t make the grade oral practices, black and blue a verify of ill-fitting bridge and other easier materials for the scale, incapable nourishment, among other things some long-term attacks a confirm of germs or perhaps worms. If oral cancers are determined far and wide the earliest stages, remedy is regularly extremely effective.

Complications associated mutually surgical treatment associated by the whole of Oral cancers is:

• Particularly mutilating with use to interested individual.

• Cosmetically beyond a shadow of a doubt not suitable

• Extreme pragmatic disadvantages associated with ingesting, hearsay in debut to feeding on.

• Recurrences beyond a shadow of a doubt not controllable by any mean abaft wards medical procedures.

• Small life span after surgery per mutilation.

That is sure thing because nearly all of situations in oral cancers throughout India are regularly stage 3 and later. The laser treatment for oral cancer and laser treatment for mouth cancer are literally effective than surgical procedure.

New Prostate Cancer Treatments Today: Zytiga And The Yunzi Mushroom?

This week two developments in prostate cancer have been unveiled. First, Zytiga (abiraterone acetate), an ingested pill treatment, has been found to potentially extend life by up to four months in men with spreading cancer who have already been treated with chemotherapy. Second, compound found in “turkey-tail,” or Yunzi mushrooms, called polysaccharopeptide (PSP), is 100% effective for protecting against prostate tumor growth in laboratory rodents.

According to the Centers for Disease Control and Prevention, prostate cancer is the second most frequently diagnosed form of cancer among men in the U.S., following skin cancer. More than 220,000 men develop the condition each year, the organization notes.

Okay, so let’s start with the manufactured remedy that can allow prostate cancer victims live longer.

The new drug Zytiga, which was approved by the FDA in April, inhibits a protein that helps form male hormones. The findings may help reshape the way doctors view and treat advanced prostate cancer. Men who took the pill also saw greater responses in levels of prostate-specific antigen (PSA) than men who received placebo. Elevated levels of PSA may be a marker for prostate cancer.

Those men who received steroid therapy along with the new pill survived for 14.8 months, on average, compared with 10.9 months seen among those who received a placebo along with steroids. This translated into a 34% reduction in risk of dying, the study shows.

Now for the Yunzi (Coriolus versicolor) mushroom. Recent studies have indicated that there may be some scientific proof behind several natural medical treatments that have been used for hundreds of years in Asian cultures.

Lead researcher Patrick Ling comments:

“In the past, other inhibitors tested in research trials have been shown to be up to 70% effective, but we’re seeing 100% of this tumor prevented from developing with PSP.”

As stated, 100% of the mice that fed with water only developed prostate tumors at the end of experiment, no tumors could be found in any of the mice fed with PSP, suggesting that PSP treatment can completely inhibit prostate tumor formation. Our results not only demonstrated the intriguing anti-CSC effect of PSP, but also revealed, for the first time, the surprising chemopreventive property of oral PSP consumption against prostate cancer.

Coriolus versicolor is a mushroom of the Basidiomycetes class. It was used initially in Traditional Chinese medicine as a tonic, but recent studies suggest that it has immunostimulant and anti-tumor properties. Polysaccharide-K (PSK), known in the United States as PSP, a proprietary product derived from Coriolus, was developed for cancer treatment in Japan. When used as an adjuvant, PSK appears to improve survival rates in patients with gastric and colorectal cancers.

One clinical study demonstrated that when used in conjunction with chemotherapy, PSP may benefit patients with advanced non-small cell lung cancer. Other clinical studies using Coriolus extract alone or in combination with other botanicals also suggest positive immunomodulatory effects. However, studies on breast cancer, hepatocellular carcinoma, and leukemia produced mixed results. A hot water extract of Coriolus, VPS, was found to enhance development of large intestinal tumors in mice. Coriolus extracts are generally well tolerated but minor adverse effects have been reported.

Sources: National Institute of Health, The New England Journal of Medicine and The Public Library of Science

Written by www.prirodnolecenje.in.rs